Research in our lab takes place at the interface between the fields of Organic Synthesis, Bioorganic Chemistry and Catalysis.

We are interested in utilizing organic chemistry tools for solving the problems in the field of biology. Our focus is development of new chemical reactions, catalysis and ligation methodologies for synthesis of biological molecules.


Overview:

The goal of Raj lab is to develop new chemical reactions including catalysts for the synthesis of proteins, peptides and bioconjugates. Most importantly, we are interested in reactions and catalysts that work well in the aqueous medium. The Raj group also seeks chemical methods for synthesis of uniquely structured peptides, mimicking secondary structures, for inhibiting protein-protein interactions implicated in disease states. The unique structure of peptide is responsible for both the stability and biological activities. All of these efforts utilize organic chemistry tools, biochemical techniques and structural characterization.